Special Section: Cancer

نویسنده

  • Robin A. Weiss
چکیده

The study of animal retroviruses has yielded fundamental insight into molecular pathways of carcinogenesis, while human retroviruses predispose infected persons to develop malignant disease. Human T-cell lymphotropic virus type I (HTLV-I) causes adult Tcell leukaemia. Human immunodeficiency virus types 1 and 2 (HIV-1, HIV-2) indirectly cause lymphoma, Kaposi’s sarcoma and cervical carcinoma by allowing the DNA viruses underlying these tumours to exert their oncogenic effects in the immunosuppressed host. Human endogenous retroviral genomes may be linked with myeloproliferative disease. Retroviruses may also be put to use in gene therapy for human cancer.

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تاریخ انتشار 2001